|
|
thiamine_diphosphate + phosphate + H+ <=> thiamine_triphosphate + H2O + H+
|
3.6.1.28
thiamine-triphosphatase
|
–
|
MK
|
|
BRENDA:
BR22768
KEGG:
R00618
MetaCyc:
RXN0-7041;
THIAMIN-TRIPHOSPHATASE-RXN
SABIO-RK:
1008
|
|
|
|
thiamine_phosphate + ATP <=> thiamine_diphosphate + ADP
|
2.7.1.21
thymidine kinase
2.7.4.12
T2-induced deoxynucleotide kinase
2.7.4.13
(deoxy)nucleoside-phosphate kinase
2.7.4.16
thiamine-phosphate kinase
2.7.4.3
adenylate kinase
2.7.4.4
nucleoside-phosphate kinase
2.7.4.8
guanylate kinase
2.7.4.9
dTMP kinase
|
–
–
–
–
–
–
–
–
|
BMK
|
|
BRENDA:
BR47844;
BR48076
KEGG:
R00617;
R02094
MetaCyc:
DTMPKI-RXN;
THI-P-KIN-RXN
SABIO-RK:
1007;
14622;
91
|
|
|
|
thiamine + ATP <=> H+ + thiamine_diphosphate + AMP
|
2.7.6.2
thiamine diphosphokinase
|
–
|
BMK
|
|
BRENDA:
BR47855
KEGG:
R00619
MetaCyc:
THIAMIN-PYROPHOSPHOKINASE-RXN
|
|
|
|
thiamine_diphosphate + ATP <=> thiamine_triphosphate + ADP
|
2.7.4.15
thiamine-diphosphate kinase
|
–
|
MK
|
|
BRENDA:
BR48072
KEGG:
R00616
MetaCyc:
THIAMIN-DIPHOSPHATE-KINASE-RXN
|
|
|
|
H+ + thiamine_diphosphate + ADP <=> adenosine_thiamine_triphosphate + phosphate
|
2.7.7
2.7.7.B3
|
–
–
|
|
|
BRENDA:
BR49082
MetaCyc:
RXN0-5291
|
|
|
|
thiamine_diphosphate + H2O <=> H+ + thiamine_phosphate + phosphate
|
3.1.3.1
alkaline phosphatase
3.1.3.100
thiamine phosphate phosphatase
3.1.3.2
acid phosphatase
3.6.1
3.6.1.15
nucleoside-triphosphate phosphatase
3.6.1.28
thiamine-triphosphatase
3.6.1.5
apyrase
3.6.1.55
8-oxo-dGTP diphosphatase
3.6.1.6
nucleoside diphosphate phosphatase
|
–
–
–
–
–
–
–
–
–
|
K
|
|
BRENDA:
BS141322;
BS141393
KEGG:
R00615;
R02092
MetaCyc:
RXN-14213;
RXN0-3542
SABIO-RK:
495;
9603
|
|
|
|
H+ + pyruvate + thiamine_diphosphate <=> 2-hydroxyethyl-ThPP + CO2
|
1.2.4.1
pyruvate dehydrogenase (acetyl-transferring)
2.2.1.6
acetolactate synthase
4.1.1.1
pyruvate decarboxylase
|
–
–
–
|
K
|
|
KEGG:
R00014
MetaCyc:
RXN-12583
SABIO-RK:
6479
|
|
|
|
(S)-2-Hydroxy-2-methyl-3-oxobutanoate + thiamine_diphosphate <=> 2-hydroxyethyl-ThPP + pyruvate
|
2.2.1.6
acetolactate synthase
|
–
|
|
|
KEGG:
R04672
MetaCyc:
RXN-14037
|
|
|
|
2-oxoglutarate + thiamine_diphosphate <=> 3-carboxy-1-hydroxypropyl-ThPP + CO2
|
1.2.4.2
oxoglutarate dehydrogenase (succinyl-transferring)
|
–
|
K
|
|
KEGG:
R00621
SABIO-RK:
243
|
|
|
|
acetaldehyde + thiamine_diphosphate <=> 2-hydroxyethyl-ThPP
|
4.1.1.1
pyruvate decarboxylase
|
–
|
K
|
|
KEGG:
R00755
|
|
|
|
2-acetolactate + thiamine_diphosphate <=> 2-hydroxyethyl-ThPP + pyruvate
|
2.2.1.6
acetolactate synthase
|
–
|
|
|
KEGG:
R03050
|
|
|
|
2-hydroxyethyl-ThPP + Enzyme_N6-(lipoyl)lysine <=> [dihydrolipoyllysine-residue_acetyltransferase]_S-acetyldihydrolipoyllysine + thiamine_diphosphate
|
1.2.4.1
pyruvate dehydrogenase (acetyl-transferring)
|
–
|
K
|
|
KEGG:
R03270
|
|
|
|
3-carboxy-1-hydroxypropyl-ThPP + Enzyme_N6-(lipoyl)lysine <=> [dihydrolipoyllysine-residue_succinyltransferase]_S-succinyldihydrolipoyllysine + thiamine_diphosphate
|
1.2.4.2
oxoglutarate dehydrogenase (succinyl-transferring)
|
–
|
K
|
|
KEGG:
R03316
|
|
|
|
2-oxobutyrate + 2-hydroxyethyl-ThPP <=> (S)-2-hydroxy-2-ethyl-3-oxobutanoate + thiamine_diphosphate
|
2.2.1.6
acetolactate synthase
|
–
|
|
|
KEGG:
R04673
|
|
|
|
D-xylulose_5-phosphate + thiamine_diphosphate <=> alpha,beta-Dihydroxyethyl-TPP + D-glyceraldehyde_3-phosphate
|
2.2.1.1
transketolase
2.2.1.3
formaldehyde transketolase
|
–
–
|
|
|
KEGG:
R06861
|
|
|
|
alpha,beta-Dihydroxyethyl-TPP + formaldehyde <=> thiamine_diphosphate + dihydroxyacetone
|
2.2.1.3
formaldehyde transketolase
|
–
|
|
|
KEGG:
R06862
|
|
|
|
sedoheptulose_7-phosphate + thiamine_diphosphate <=> alpha,beta-Dihydroxyethyl-TPP + D-ribose_5-phosphate
|
2.2.1.1
transketolase
|
–
|
|
|
KEGG:
R06863
|
|
|
|
2-oxoisovalerate + thiamine_diphosphate <=> 2-Methyl-1-hydroxypropyl-ThPP + CO2
|
1.2.4.4
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
|
–
|
K
|
|
KEGG:
R07599
|
|
|
|
2-Methyl-1-hydroxypropyl-ThPP + Enzyme_N6-(lipoyl)lysine <=> [dihydrolipoyllysine-residue_(2-methylpropanoyl)transferase]_S-(2-methylpropanoyl)dihydrolipoyllysine + thiamine_diphosphate
|
1.2.4.4
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
|
–
|
K
|
|
KEGG:
R07600
|
|
|
|
4-methyl-2-oxopentanoate + thiamine_diphosphate <=> 3-Methyl-1-hydroxybutyl-ThPP + CO2
|
1.2.4.4
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
|
–
|
K
|
|
KEGG:
R07601
|
|
|
|
3-Methyl-1-hydroxybutyl-ThPP + Enzyme_N6-(lipoyl)lysine <=> [dihydrolipoyllysine-residue_(2-methylpropanoyl)transferase]_S-(3-methylbutanoyl)dihydrolipoyllysine + thiamine_diphosphate
|
1.2.4.4
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
|
–
|
K
|
|
KEGG:
R07602
|
|
|
|
(S)-3-methyl-2-oxopentanoate + thiamine_diphosphate <=> 2-Methyl-1-hydroxybutyl-ThPP + CO2
|
1.2.4.4
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
|
–
|
K
|
|
KEGG:
R07603
|
|
|
|
2-Methyl-1-hydroxybutyl-ThPP + Enzyme_N6-(lipoyl)lysine <=> [dihydrolipoyllysine-residue_(2-methylpropanoyl)transferase]_S-(2-methylbutanoyl)dihydrolipoyllysine + thiamine_diphosphate
|
1.2.4.4
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
|
–
|
K
|
|
KEGG:
R07604
|
|
|
|
2-oxobutyrate + thiamine_diphosphate <=> 2-(alpha-Hydroxypropyl)thiamine_diphosphate + CO2
|
1.2.4.4
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
|
–
|
K
|
|
KEGG:
R10996
|
|
|
|
2-(alpha-Hydroxypropyl)thiamine_diphosphate + Enzyme_N6-(lipoyl)lysine <=> Enzyme_N6-(S-propyldihydrolipoyl)lysine + thiamine_diphosphate
|
1.2.4.4
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
|
–
|
K
|
|
KEGG:
R10997
|
|
|
|
thiamine_diphosphate + ADP <=> thiamine_triphosphate + AMP
|
2.7.4.3
adenylate kinase
|
–
|
K
|
|
KEGG:
R11319
|
|
|
|
2-hydroxyethyl-ThPP + [pyruvate_dehydrogenase_E2_protein]_N6-lipoyl-L-lysine <=> [pyruvate_dehydrogenase_E2_protein]_N6-S-acetyldihydrolipoyl-L-lysine + thiamine_diphosphate
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-12508
|
|
|
|
CTP + thiamine_diphosphate <=> CDP + thiamine_triphosphate
|
2.7.4.15
thiamine-diphosphate kinase
|
–
|
|
|
BRENDA:
BS359782
|
|
|
|
thiamine_diphosphate + ATP <=> adenosine_thiamine_triphosphate + diphosphate
|
2.7.7.B3
|
–
|
|
|
BRENDA:
BR49083
|
|
|
|
ATP + H2O + thiamine_diphosphate-[thiamine-binding_protein_ThiB][side_1] <=> ADP + phosphate + thiamine_diphosphate + [thiamine-binding_protein_ThiB][side_1]
|
7.6.2.15
ABC-type thiamine transporter
|
–
|
|
|
BRENDA:
BS448466
|
|
|
|
ATP + H2O + thiamine_diphosphate-[thiamine-binding_protein][side_1] <=> ADP + phosphate + thiamine_diphosphate + [thiamine-binding_protein][side_1]
|
7.6.2.15
ABC-type thiamine transporter
|
–
|
|
|
BRENDA:
BS448467
|
|
|
|
UTP + thiamine <=> UMP + thiamine_diphosphate
|
2.7.6.2
thiamine diphosphokinase
|
–
|
|
|
BRENDA:
BS358311
|
|
|
|
GTP + thiamine <=> GMP + thiamine_diphosphate
|
2.7.6.2
thiamine diphosphokinase
|
–
|
|
|
BRENDA:
BS358313
|
|
|
|
CTP + thiamine <=> CMP + thiamine_diphosphate
|
2.7.6.2
thiamine diphosphokinase
|
–
|
|
|
BRENDA:
BS358312
|
|
|
|
thiamine_diphosphate + 2 H2O <=> thiamine + 2 phosphate
|
3.1.3.2
acid phosphatase
3.6.1.5
apyrase
|
–
–
|
|
|
BRENDA:
BS141374
|
|
|
|
thiamine_diphosphate + H2O <=> thiamine + diphosphate
|
3.6.1.9
nucleotide diphosphatase
|
–
|
|
|
BRENDA:
BS456827
|
|